Modeling Familial Cancer with Induced Pluripotent Stem Cells

In vitro modeling of human disease has recently become feasible with induced pluripotent stem cell (iPSC) technology. Here, we established patient-derived iPSCs from a Li-Fraumeni Syndrome (LFS) family and investigated the role of mutant p53 in the development of osteosarcoma (OS). LFS iPSC-derived...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Lee, Dung-Fang, Su, Jie, Kim, Huen Suk, Chang, Betty, Papatsenko, Dmitri, Zhao, Ruiying, Yuan, Ye, Gingold, Julian, Xia, Weiya, Darr, Henia, Mirzayans, Razmik, Hung, Mien-Chie, Schaniel, Christoph, Lemischka, Ihor R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4397979/
https://ncbi.nlm.nih.gov/pubmed/25860607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.02.045
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