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Bone marrow-derived macrophages from aged rats are more responsive to inflammatory stimuli

BACKGROUND: Lipopolysaccharide (LPS) and interferon-γ (IFNγ) increase expression of tumour necrosis factor-α (TNFα) that characterizes the M1 activation state of macrophages. Whereas it is accepted that the immune system undergoes changes with age, there is inconsistency in the literature with respe...

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Publicado en:J Neuroinflammation
Main Authors: Barrett, James P, Costello, Derek A, O’Sullivan, Joan, Cowley, Thelma R, Lynch, Marina A
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4397943/
https://ncbi.nlm.nih.gov/pubmed/25890218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-015-0287-7
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