SapC-DOPS nanovesicles induce Smac- and Bax-dependent apoptosis through mitochondrial activation in neuroblastomas

BACKGROUND: High toxicity, morbidity and secondary malignancy render chemotherapy of neuroblastoma inefficient, prompting the search for novel compounds. Nanovesicles offer great promise in imaging and treatment of cancer. SapC-DOPS, a stable nanovesicle formed from the lysosomal protein saposin C a...

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Bibliografiske detaljer
Udgivet i:Mol Cancer
Main Authors: Sulaiman, Mahaboob K, Chu, Zhengtao, Blanco, Victor M, Vallabhapurapu, Subrahmanya D, Franco, Robert S, Qi, Xiaoyang
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2015
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4397704/
https://ncbi.nlm.nih.gov/pubmed/25889084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-015-0336-y
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