Polyamines: Predictive Biomarker for HIV-Associated Neurocognitive Disorders

OBJECTIVES: Spermidine/spermine-N(1)-acetytransferase (SSAT) is the key enzyme in the catabolism of polyamines that are involved in regulating NMDA functioning. Over expression of SSAT leads to abnormal metabolic cycling and may disrupt NMDA receptor signaling. In fact, the HIV protein Tat induces n...

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Pubblicato in:J AIDS Clin Res
Autori principali: Merali, Salim, Barrero, Carlos A., Sacktor, Ned C., Haughey, Norman J., Datta, Prasun K., Langford, Dianne, Khalili, Kamel
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4397651/
https://ncbi.nlm.nih.gov/pubmed/25893137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4172/2155-6113.1000312
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