Polyamines: Predictive Biomarker for HIV-Associated Neurocognitive Disorders

OBJECTIVES: Spermidine/spermine-N(1)-acetytransferase (SSAT) is the key enzyme in the catabolism of polyamines that are involved in regulating NMDA functioning. Over expression of SSAT leads to abnormal metabolic cycling and may disrupt NMDA receptor signaling. In fact, the HIV protein Tat induces n...

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Bibliografiska uppgifter
I publikationen:J AIDS Clin Res
Huvudupphovsmän: Merali, Salim, Barrero, Carlos A., Sacktor, Ned C., Haughey, Norman J., Datta, Prasun K., Langford, Dianne, Khalili, Kamel
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4397651/
https://ncbi.nlm.nih.gov/pubmed/25893137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4172/2155-6113.1000312
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