Social defeat stress-induced sensitization and escalated cocaine self-administration: The role of ERK signaling in the rat ventral tegmental area

RATIONALE: Intermittent social defeat stress can induce neuroadaptations that promote compulsive drug taking. Within the mesocorticolimbic circuit, repeated cocaine administration activates extracellular signal-regulated kinase (ERK). OBJECTIVE: The present experiments examine whether changes in ERK...

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Publicado en:Psychopharmacology (Berl)
Main Authors: Yap, Jasmine J., Chartoff, Elena H., Holly, Elizabeth N., Potter, David N., Carlezon, William A., Miczek, Klaus A.
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4397167/
https://ncbi.nlm.nih.gov/pubmed/25373870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-014-3796-7
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