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CRF type 1 receptor antagonism in ventral tegmental area of adolescent rats during social defeat: Prevention of escalated cocaine self-administration in adulthood and behavioral adaptations during adolescence

BACKGROUND: Activation of corticotropin releasing factor type 1 receptors (CRF-R1) in the ventral tegmental area (VTA) represents a critical mechanism for social defeat to escalate cocaine self-administration in adult rats. OBJECTIVE: We determined the acute effect of a CRF-R1 antagonist (CP376395)...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Psychopharmacology (Berl)
Prif Awduron: Burke, Andrew R., DeBold, Joseph F., Miczek, Klaus A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4919183/
https://ncbi.nlm.nih.gov/pubmed/27251131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-016-4336-4
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