Bioavailability, Biodistribution, and CNS Toxicity of Clinical-Grade Parvovirus H1 after Intravenous and Intracerebral Injection in Rats

The autonomous parvovirus H1 (H1PV) is transmitted in rodent populations. The natural host is the rat, in which H1PV infection is pathogenic only in fetuses and newborns. H1PV infection of human cancer cells leads to strong oncolytic effects in preclinical models. In preparation for a clinical trial...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Comp Med
Egile Nagusiak: Geletneky, Karsten, Leoni, Anne-Laure, Pohlmeyer-Esch, Gabriele, Loebhard, Stephanie, Leuchs, Barbara, Hoefer, Constance, Jochims, Karin, Dahm, Michael, Huber, Bernard, Rommelaere, Jean, Krebs, Ottheinz, Hajda, Jacek
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Association for Laboratory Animal Science 2015
Gaiak:
Rat Models
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4396927/
https://ncbi.nlm.nih.gov/pubmed/25730755
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