Bioavailability, Biodistribution, and CNS Toxicity of Clinical-Grade Parvovirus H1 after Intravenous and Intracerebral Injection in Rats

The autonomous parvovirus H1 (H1PV) is transmitted in rodent populations. The natural host is the rat, in which H1PV infection is pathogenic only in fetuses and newborns. H1PV infection of human cancer cells leads to strong oncolytic effects in preclinical models. In preparation for a clinical trial...

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Detalhes bibliográficos
Publicado no:Comp Med
Main Authors: Geletneky, Karsten, Leoni, Anne-Laure, Pohlmeyer-Esch, Gabriele, Loebhard, Stephanie, Leuchs, Barbara, Hoefer, Constance, Jochims, Karin, Dahm, Michael, Huber, Bernard, Rommelaere, Jean, Krebs, Ottheinz, Hajda, Jacek
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for Laboratory Animal Science 2015
Assuntos:
Rat Models
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4396927/
https://ncbi.nlm.nih.gov/pubmed/25730755
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