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55.2, a Phage T4 ORFan Gene, Encodes an Inhibitor of Escherichia coli Topoisomerase I and Increases Phage Fitness
Topoisomerases are enzymes that alter the topological properties of DNA. Phage T4 encodes its own topoisomerase but it can also utilize host-encoded topoisomerases. Here we characterized 55.2, a phage T4 predicted ORF of unknown function. High levels of expression of the cloned 55.2 gene are toxic i...
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| Publicado no: | PLoS One |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4396842/ https://ncbi.nlm.nih.gov/pubmed/25875362 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0124309 |
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