Distinct Metabolomic Signatures Are Associated with Longevity in Humans

Alterations in metabolism influence lifespan in experimental models, but data in humans are lacking. Here we use liquid chromatography/mass spectrometry to quantify 217 plasma metabolites and examine their relation to longevity in a large cohort of men and women. In 647 individuals followed for up t...

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Udgivet i:Nat Commun
Main Authors: Cheng, Susan, Larson, Martin G., McCabe, Elizabeth L., Murabito, Joanne M., Rhee, Eugene P., Ho, Jennifer E., Jacques, Paul F., Ghorbani, Anahita, Magnusson, Martin, Souza, Amanda L., Deik, Amy A., Pierce, Kerry A., Bullock, Kevin, O’Donnell, Christopher J., Melander, Olle, Clish, Clary B., Vasan, Ramachandran S., Gerszten, Robert E., Wang, Thomas J.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4396657/
https://ncbi.nlm.nih.gov/pubmed/25864806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7791
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