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PARP1 and phospho-p65 protein expression is increased in human HER2-positive breast cancers

PURPOSE: Previous studies have shown that basal breast cancers, which may have an inherent “BRCAness” phenotype and sensitivity to inhibitors of poly (ADP-Ribose) polymerase (PARP), express elevated levels of PARP1. Our lab recently reported that HER2+ breast cancers also exhibit sensitivity to PARP...

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Detalhes bibliográficos
Publicado no:Breast Cancer Res Treat
Main Authors: Stanley, Jennifer, Klepczyk, Lisa, Keene, Kimberly, Wei, Shi, Li, Yufeng, Forero, Andres, Grizzle, William, Wielgos, Monica, Brazelton, Jason, LoBuglio, Albert F., Yang, Eddy S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4396624/
https://ncbi.nlm.nih.gov/pubmed/25833211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10549-015-3359-6
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