PON3 knockout mice are susceptible to obesity, gallstone formation, and atherosclerosis

We report the engineering and characterization of paraoxonase-3 knockout mice (Pon3KO). The mice were generally healthy but exhibited quantitative alterations in bile acid metabolism and a 37% increased body weight compared to the wild-type mice on a high fat diet. PON3 was enriched in the mitochond...

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Veröffentlicht in:FASEB J
Hauptverfasser: Shih, Diana M., Yu, Janet M., Vergnes, Laurent, Dali-Youcef, Nassim, Champion, Matthew D., Devarajan, Asokan, Zhang, Peixiang, Castellani, Lawrence W., Brindley, David N., Jamey, Carole, Auwerx, Johan, Reddy, Srinivasa T., Ford, David A., Reue, Karen, Lusis, Aldons J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Federation of American Societies for Experimental Biology 2015
Schlagworte:
Research Communication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4396607/
https://ncbi.nlm.nih.gov/pubmed/25477283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.14-260570
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