S-nitrosoglutathione reductase–dependent PPARγ denitrosylation participates in MSC-derived adipogenesis and osteogenesis

Bone marrow–derived mesenchymal stem cells (MSCs) are a common precursor of both adipocytes and osteoblasts. While it is appreciated that PPARγ regulates the balance between adipogenesis and osteogenesis, the roles of additional regulators of this process remain controversial. Here, we show that MSC...

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Vydáno v:J Clin Invest
Hlavní autoři: Cao, Yenong, Gomes, Samirah A., Rangel, Erika B., Paulino, Ellena C., Fonseca, Tatiana L., Li, Jinliang, Teixeira, Marilia B., Gouveia, Cecilia H., Bianco, Antonio C., Kapiloff, Michael S., Balkan, Wayne, Hare, Joshua M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2015
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4396480/
https://ncbi.nlm.nih.gov/pubmed/25798618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI73780
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