Analysis of Dibenzo[def,p]chrysene-Deoxyadenosine Adducts in Wild-Type and Cytochrome P450 1b1 Knockout Mice using Stable-Isotope Dilution UHPLC-MS/MS

The polycyclic aromatic hydrocarbon (PAH), dibenzo[def,p]chrysene (DBC; also known as dibenzo[a,l]pyrene), is a potent carcinogen in animal models and a class 2A human carcinogen. Recent investigations into DBC-mediated toxicity identified DBC as a potent immunosuppressive agent similar to the well-...

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Bibliografske podrobnosti
izdano v:Mutat Res Genet Toxicol Environ Mutagen
Main Authors: Harper, Tod A., Morré, Jeff, Lauer, Fredine T., McQuistan, Tammie J., Hummel, Jessica M., Burchiel, Scott W., Williams, David E.
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4395865/
https://ncbi.nlm.nih.gov/pubmed/25868132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mrgentox.2015.03.007
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