First-in-man Phase 1 Clinical Trial of Gene Therapy for Advanced Pancreatic Cancer: Safety, Biodistribution, and Preliminary Clinical Findings

This phase 1 trial was aimed to determine the safety, pharmacokinetics, and preliminary clinical activity of CYL-02, a nonviral gene therapy product that sensitizes pancreatic cancer cells to chemotherapy. CYL-02 was administrated using endoscopic ultrasound in 22 patients with pancreatic cancer tha...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Buscail, Louis, Bournet, Barbara, Vernejoul, Fabienne, Cambois, Gilles, Lulka, Hubert, Hanoun, Naïma, Dufresne, Marlène, Meulle, Aline, Vignolle-Vidoni, Alix, Ligat, Laetitia, Saint-Laurent, Nathalie, Pont, Frédéric, Dejean, Sébastien, Gayral, Marion, Martins, Frédéric, Torrisani, Jérôme, Barbey, Odile, Gross, Fabian, Guimbaud, Rosine, Otal, Philippe, Lopez, Frédéric, Tiraby, Gérard, Cordelier, Pierre
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4395782/
https://ncbi.nlm.nih.gov/pubmed/25586689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2015.1
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