HDAC Inhibitors Target HDAC5, Upregulate MicroRNA-125a-5p, and Induce Apoptosis in Breast Cancer Cells

Histone deacetylase inhibitors (HDACi) are novel clinical anticancer drugs that inhibit HDAC gene expression and induce cell apoptosis in human cancers. Nevertheless, the detailed mechanism or the downstream HDAC targets by which HDACi mediates apoptosis in human breast cancer cells remains unclear....

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Hsieh, Tsung-Hua, Hsu, Chia-Yi, Tsai, Cheng-Fang, Long, Cheng-Yu, Wu, Chin-Hu, Wu, Deng-Chyang, Lee, Jau-Nan, Chang, Wei-Chun, Tsai, Eing-Mei
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4395776/
https://ncbi.nlm.nih.gov/pubmed/25531695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2014.247
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