A Fast and Scalable Kymograph Alignment Algorithm for Nanochannel-Based Optical DNA Mappings

Optical mapping by direct visualization of individual DNA molecules, stretched in nanochannels with sequence-specific fluorescent labeling, represents a promising tool for disease diagnostics and genomics. An important challenge for this technique is thermal motion of the DNA as it undergoes imaging...

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Veröffentlicht in:PLoS One
Hauptverfasser: Noble, Charleston, Nilsson, Adam N., Freitag, Camilla, Beech, Jason P., Tegenfeldt, Jonas O., Ambjörnsson, Tobias
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4395267/
https://ncbi.nlm.nih.gov/pubmed/25875920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0121905
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