Ex Vivo Cytosolic Delivery of Functional Macromolecules to Immune Cells

Intracellular delivery of biomolecules, such as proteins and siRNAs, into primary immune cells, especially resting lymphocytes, is a challenge. Here we describe the design and testing of microfluidic intracellular delivery systems that cause temporary membrane disruption by rapid mechanical deformat...

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Pubblicato in:PLoS One
Autori principali: Sharei, Armon, Trifonova, Radiana, Jhunjhunwala, Siddharth, Hartoularos, George C., Eyerman, Alexandra T., Lytton-Jean, Abigail, Angin, Mathieu, Sharma, Siddhartha, Poceviciute, Roberta, Mao, Shirley, Heimann, Megan, Liu, Sophia, Talkar, Tanya, Khan, Omar F., Addo, Marylyn, von Andrian, Ulrich H., Anderson, Daniel G., Langer, Robert, Lieberman, Judy, Jensen, Klavs F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4395260/
https://ncbi.nlm.nih.gov/pubmed/25875117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0118803
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