In vivo production of human factor VII in mice after intrasplenic implantation of primary fibroblasts transfected by receptor-mediated, adenovirus-augmented gene delivery.

Hemophilia A is caused by defects in the factor VIII gene. This results in life-threatening hemorrhages and severe arthropathies. Today, hemophiliacs are treated with human blood-derived factor VIII. In the future, it may be possible to use gene therapy to avoid long-term complications of convention...

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Detalles Bibliográficos
Main Authors: Zatloukal, K, Cotten, M, Berger, M, Schmidt, W, Wagner, E, Birnstiel, M L
Formato: Artigo
Idioma:Inglês
Publicado: 1994
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC43949/
https://ncbi.nlm.nih.gov/pubmed/8197198
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