Heterosubtypic Protection Conferred by the Human Monoclonal Antibody PN-SIA28 against Influenza A Virus Lethal Infections in Mice

PN-SIA28 is a human monoclonal antibody (Hu-MAb) targeting highly conserved epitopes within the stem portion of the influenza virus hemagglutinin (HA) (N. Clementi, et al, PLoS One 6:e28001, 2011, http://dx.doi.org/10.1371/journal.pone.0028001). Previous in vitro studies demonstrated PN-SIA28 neutra...

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Detalles Bibliográficos
Publicado en:Antimicrob Agents Chemother
Autores principales: Retamal, Miguel, Abed, Yacine, Rhéaume, Chantal, Cappelletti, Francesca, Clementi, Nicola, Mancini, Nicasio, Clementi, Massimo, Burioni, Roberto, Boivin, Guy
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2015
Materias:
Antiviral Agents
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394790/
https://ncbi.nlm.nih.gov/pubmed/25691648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00118-15
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