β-Lactams Enhance Daptomycin Activity against Vancomycin-Resistant Enterococcus faecalis and Enterococcus faecium in In Vitro Pharmacokinetic/Pharmacodynamic Models

Enterococcus faecalis and Enterococcus faecium are frequently resistant to vancomycin and β-lactams. In enterococcal infections with reduced glycopeptide susceptibility, combination therapy is often administered. Our objective was to conduct pharmacokinetic/pharmacodynamic (PK/PD) models to evaluate...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Smith, Jordan R., Barber, Katie E., Raut, Animesh, Rybak, Michael J.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2015
Subjects:
Experimental Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394769/
https://ncbi.nlm.nih.gov/pubmed/25753639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00053-15
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