Tenovin-6-mediated inhibition of SIRT1/2 induces apoptosis in acute lymphoblastic leukemia (ALL) cells and eliminates ALL stem/progenitor cells

BACKGROUND: Acute lymphoblastic leukemia (ALL) is a heterogeneous group of malignant disorders derived from B- or T-cell lymphoid progenitor cells. ALL often is refractory to or relapses after treatment; thus, novel targeted therapy for ALL is urgently needed. In the present study, we initially foun...

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Vydáno v:BMC Cancer
Hlavní autoři: Jin, Yanli, Cao, Qi, Chen, Chun, Du, Xin, Jin, Bei, Pan, Jingxuan
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2015
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394409/
https://ncbi.nlm.nih.gov/pubmed/25884180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1282-1
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