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Evaluating Many Treatments and Biomarkers in Oncology: A New Design

There is a pressing need for more-efficient trial designs for biomarker-stratified clinical trials. We suggest a new approach to trial design that links novel treatment evaluation with the concurrent evaluation of a biomarker within a confirmatory phase II/III trial setting. We describe a new protoc...

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Detalhes bibliográficos
Publicado no:J Clin Oncol
Main Authors: Kaplan, Richard, Maughan, Timothy, Crook, Angela, Fisher, David, Wilson, Richard, Brown, Louise, Parmar, Mahesh
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394353/
https://ncbi.nlm.nih.gov/pubmed/24248692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2013.50.7905
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