Discovery of a Potent and Orally Bioavailable Dual Antagonist of CC Chemokine Receptors 2 and 5

[Image: see text] We describe the hybridization of our previously reported acyclic and cyclic CC chemokine receptor 2 (CCR2) antagonists to lead to a new series of dual antagonists of CCR2 and CCR5. Installation of a γ-lactam as the spacer group and a quinazoline as a benzamide mimetic improved oral...

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Gepubliceerd in:ACS Med Chem Lett
Hoofdauteurs: Carter, Percy H., Brown, Gregory D., Cherney, Robert J., Batt, Douglas G., Chen, Jing, Clark, Cheryl M., Cvijic, Mary Ellen, Duncia, John V., Ko, Soo S., Mandlekar, Sandhya, Mo, Ruowei, Nelson, David J., Pang, Jian, Rose, Anne V., Santella, Joseph B., Tebben, Andrew J., Traeger, Sarah C., Xu, Songmei, Zhao, Qihong, Barrish, Joel C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Chemical Society 2015
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394346/
https://ncbi.nlm.nih.gov/pubmed/25893046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500505q
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