Discovery of a Potent and Orally Bioavailable Dual Antagonist of CC Chemokine Receptors 2 and 5

[Image: see text] We describe the hybridization of our previously reported acyclic and cyclic CC chemokine receptor 2 (CCR2) antagonists to lead to a new series of dual antagonists of CCR2 and CCR5. Installation of a γ-lactam as the spacer group and a quinazoline as a benzamide mimetic improved oral...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:ACS Med Chem Lett
मुख्य लेखकों: Carter, Percy H., Brown, Gregory D., Cherney, Robert J., Batt, Douglas G., Chen, Jing, Clark, Cheryl M., Cvijic, Mary Ellen, Duncia, John V., Ko, Soo S., Mandlekar, Sandhya, Mo, Ruowei, Nelson, David J., Pang, Jian, Rose, Anne V., Santella, Joseph B., Tebben, Andrew J., Traeger, Sarah C., Xu, Songmei, Zhao, Qihong, Barrish, Joel C.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Chemical Society 2015
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394346/
https://ncbi.nlm.nih.gov/pubmed/25893046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500505q
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