Discovery of a Potent and Orally Bioavailable Dual Antagonist of CC Chemokine Receptors 2 and 5

[Image: see text] We describe the hybridization of our previously reported acyclic and cyclic CC chemokine receptor 2 (CCR2) antagonists to lead to a new series of dual antagonists of CCR2 and CCR5. Installation of a γ-lactam as the spacer group and a quinazoline as a benzamide mimetic improved oral...

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Foilsithe in:ACS Med Chem Lett
Main Authors: Carter, Percy H., Brown, Gregory D., Cherney, Robert J., Batt, Douglas G., Chen, Jing, Clark, Cheryl M., Cvijic, Mary Ellen, Duncia, John V., Ko, Soo S., Mandlekar, Sandhya, Mo, Ruowei, Nelson, David J., Pang, Jian, Rose, Anne V., Santella, Joseph B., Tebben, Andrew J., Traeger, Sarah C., Xu, Songmei, Zhao, Qihong, Barrish, Joel C.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Chemical Society 2015
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394346/
https://ncbi.nlm.nih.gov/pubmed/25893046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500505q
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