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N-Glycosylation as determinant of epidermal growth factor receptor conformation in membranes
The epidermal growth factor receptor (EGFR) regulates several critical cellular processes and is an important target for cancer therapy. In lieu of a crystallographic structure of the complete receptor, atomistic molecular dynamics (MD) simulations have recently shown that they can excel in studies...
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| Publié dans: | Proc Natl Acad Sci U S A |
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| Auteurs principaux: | , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4394299/ https://ncbi.nlm.nih.gov/pubmed/25805821 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1503262112 |
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