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N-Glycosylation as determinant of epidermal growth factor receptor conformation in membranes
The epidermal growth factor receptor (EGFR) regulates several critical cellular processes and is an important target for cancer therapy. In lieu of a crystallographic structure of the complete receptor, atomistic molecular dynamics (MD) simulations have recently shown that they can excel in studies...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4394299/ https://ncbi.nlm.nih.gov/pubmed/25805821 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1503262112 |
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