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N-Glycosylation as determinant of epidermal growth factor receptor conformation in membranes

The epidermal growth factor receptor (EGFR) regulates several critical cellular processes and is an important target for cancer therapy. In lieu of a crystallographic structure of the complete receptor, atomistic molecular dynamics (MD) simulations have recently shown that they can excel in studies...

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Foilsithe in:Proc Natl Acad Sci U S A
Main Authors: Kaszuba, Karol, Grzybek, Michał, Orłowski, Adam, Danne, Reinis, Róg, Tomasz, Simons, Kai, Coskun, Ünal, Vattulainen, Ilpo
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2015
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394299/
https://ncbi.nlm.nih.gov/pubmed/25805821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1503262112
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