Cross-talk between PKA-Cβ and p65 mediates synergistic induction of PDE4B by roflumilast and NTHi

Phosphodiesterase 4B (PDE4B) plays a key role in regulating inflammation. Roflumilast, a phosphodiesterase (PDE)4-selective inhibitor, has recently been approved for treating severe chronic obstructive pulmonary disease (COPD) patients with exacerbation. However, there is also clinical evidence sugg...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Susuki-Miyata, Seiko, Miyata, Masanori, Lee, Byung-Cheol, Xu, Haidong, Kai, Hirofumi, Yan, Chen, Li, Jian-Dong
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2015
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394257/
https://ncbi.nlm.nih.gov/pubmed/25831493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1418716112
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