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The entropic contributions in vitamin B(12) enzymes still reflect the electrostatic paradigm

The catalytic power of enzymes containing coenzyme B(12) has been, in some respects, the “last bastion” for the strain hypothesis. Our previous study of this system established by a careful sampling that the major part of the catalytic effect is due to the electrostatic interaction between the ribos...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Schopf, Patrick, Mills, Matthew J. L., Warshel, Arieh
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394256/
https://ncbi.nlm.nih.gov/pubmed/25805820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1503828112
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