TCR contact residue hydrophobicity is a hallmark of immunogenic CD8(+) T cell epitopes

Despite the availability of major histocompatibility complex (MHC)-binding peptide prediction algorithms, the development of T-cell vaccines against pathogen and tumor antigens remains challenged by inefficient identification of immunogenic epitopes. CD8(+) T cells must distinguish immunogenic epito...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Chowell, Diego, Krishna, Sri, Becker, Pablo D., Cocita, Clément, Shu, Jack, Tan, Xuefang, Greenberg, Philip D., Klavinskis, Linda S., Blattman, Joseph N., Anderson, Karen S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394253/
https://ncbi.nlm.nih.gov/pubmed/25831525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1500973112
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