Engineering recombinant reoviruses with tandem repeats and a tetravirus 2A-like element for exogenous polypeptide expression

We tested a strategy for engineering recombinant mammalian reoviruses (rMRVs) to express exogenous polypeptides. One important feature is that these rMRVs are designed to propagate autonomously and can therefore be tested in animals as potential vaccine vectors. The strategy has been applied so far...

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Bibliographic Details
Main Authors: Demidenko, Aleksander A., Blattman, Joseph N., Blattman, Negin N., Greenberg, Philip D., Nibert, Max L.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2013
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3657830/
https://ncbi.nlm.nih.gov/pubmed/23630248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1220107110
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