Protein kinase D1 drives pancreatic acinar cell reprogramming and progression to intraepithelial neoplasia

The transdifferentiation of pancreatic acinar cells to a ductal phenotype (acinar-to-ductal metaplasia, ADM) occurs after injury or inflammation of the pancreas and is a reversible process. However, in the presence of activating Kras mutations or persistent epidermal growth factor receptor (EGF-R) s...

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Udgivet i:Nat Commun
Main Authors: Liou, Geou-Yarh, Döppler, Heike, Braun, Ursula B., Panayiotou, Richard, Buzhardt, Michele Scotti, Radisky, Derek C., Crawford, Howard C., Fields, Alan P., Murray, Nicole R., Wang, Q. Jane, Leitges, Michael, Storz, Peter
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394184/
https://ncbi.nlm.nih.gov/pubmed/25698580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7200
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