Efficacy of carboplatin alone and in combination with ABT888 in intracranial murine models of BRCA-mutated and BRCA-wild-type triple negative breast cancer

Patients with breast cancer brain metastases have extremely limited survival and no approved systemic therapeutics. Triple negative breast cancer (TNBC) commonly metastasizes to the brain and predicts poor prognosis. TNBC frequently harbors BRCA mutations translating to platinum sensitivity potentia...

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Udgivet i:Mol Cancer Ther
Main Authors: Karginova, Olga, Siegel, Marni B., Van Swearingen, Amanda E. D., Deal, Allison M., Adamo, Barbara, Sambade, Maria J., Bazyar, Soha, Nikolaishvili-Feinberg, Nana, Bash, Ryan, O’Neal, Sara, Sandison, Katie, Parker, Joel S., Santos, Charlene, Darr, David, Zamboni, William, Lee, Yueh Z., Miller, C. Ryan, Anders, Carey K.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394032/
https://ncbi.nlm.nih.gov/pubmed/25824335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-14-0474
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