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Valproic acid induces neuronal cell death through a novel calpain-dependent necroptosis pathway

A growing body of evidence indicates that valproic acid (VPA), a histone deacetylase (HDAC) inhibitor used to treat epilepsy and mood disorders, has HDAC-related and -unrelated neurotoxic activity, the mechanism of which is still poorly understood. We report that VPA induces neuronal cell death thro...

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Detalles Bibliográficos
Publicado en:J Neurochem
Main Authors: Bollino, Dominique, Balan, Irina, Aurelian, Laure
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4393803/
https://ncbi.nlm.nih.gov/pubmed/25581256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.13029
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