Transcriptional Regulation of N-acetylaspartate Metabolism in the 5xFAD Model of Alzheimer's Disease: Evidence for Neuron-Glia Communication During Energetic Crisis

N-acetylaspartate (NAA) provides a non-invasive clinical index of neuronal metabolic integrity across the entire neurodegenerative spectrum. While NAA function is not comprehensively defined, reductions in the brain are associated with compromised mitochondrial metabolism and are tightly linked to A...

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Bibliographic Details
Published in:Mol Cell Neurosci
Main Authors: Zaroff, Samantha, Leone, Paola, McPhee, Scott W. J., Markov, Vladimir, Francis, Jeremy S.
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4393791/
https://ncbi.nlm.nih.gov/pubmed/25766789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mcn.2015.03.009
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