Palmitate-derivatized human IL-2: a potential anticancer immunotherapeutic of low systemic toxicity

PURPOSE AND EXPERIMENTAL DESIGN: Recombinant human IL-2 (rhIL-2) is a potent cytokine and FDA-approved anticancer drug. However, its clinical use has been limited by severe toxicity, associated primarily with systemic administration with excess protein distributing freely throughout the body. We hyp...

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Detalhes bibliográficos
Publicado no:Cancer Immunol Immunother
Main Authors: Chou, Sharon H., Shetty, Aditya V., Geng, Yajun, Xu, Lipeng, Munirathinam, Gnanasekar, Pipathsouk, Anne, Tan, Isaiah, Morris, Timothy, Wang, Bin, Chen, Aoshuang, Zheng, Guoxing
Formato: Artigo
Idioma:Inglês
Publicado em: Springer-Verlag 2012
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4393711/
https://ncbi.nlm.nih.gov/pubmed/23124508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-012-1364-8
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