EZH2 inhibition sensitizes BRG1 and EGFR mutant lung tumors to TopoII inhibitors

Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide(1). Chemotherapies such as the topoisomerase II inhibitor (TopoIIi) etoposide effectively reduce disease in a minority of NSCLC patients(2,3); therefore, alternative drug targets, including epigenetic enzymes,...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Nature
Egile Nagusiak: Fillmore, Christine M., Xu, Chunxiao, Desai, Pooja T., Berry, Joanne M., Rowbotham, Samuel P., Lin, Yi-Jang, Zhang, Haikuo, Marquez, Victor E., Hammerman, Peter S., Wong, Kwok-Kin, Kim, Carla F.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2015
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4393352/
https://ncbi.nlm.nih.gov/pubmed/25629630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14122
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak