Aquaporin 1 promotes sensitivity of anthracycline chemotherapy in breast cancer by inhibiting β-catenin degradation to enhance TopoIIα activity

Anthracyclines are a class of conventional and commonly used frontline chemotherapy drugs to treat breast cancer. However, the anthracycline-based regimens can only reduce breast cancer mortality by 20–30%. Furthermore, there is no appropriate biomarker for predicting responses to this kind of chemo...

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Veröffentlicht in:Cell Death Differ
Hauptverfasser: Chong, Wei, Zhang, Huikun, Guo, Zhifang, Yang, Limin, Shao, Ying, Liu, Xiaoli, Zhao, Yawen, Wang, Zhe, Zhang, Ming, Guo, Caixia, Fu, Li, Ma, Yongjie, Gu, Feng
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7852611/
https://ncbi.nlm.nih.gov/pubmed/32814878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-020-00607-9
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