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Functional Characterization of Human T Cell Hyporesponsiveness Induced by CTLA4-Ig
During activation, T cells integrate multiple signals from APCs and cytokine milieu. The blockade of these signals can have clinical benefits as exemplified by CTLA4-Ig, which blocks interaction of B7 co-stimulatory molecules on APCs with CD28 on T cells. Variants of CTLA4-Ig, abatacept and belatace...
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| Publicado no: | PLoS One |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4393265/ https://ncbi.nlm.nih.gov/pubmed/25860138 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0122198 |
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