M1 Muscarinic Receptors Modify Oxidative Stress Response to Acetaminophen-Induced Acute Liver Injury

The role of muscarinic receptor subtypes in modulating acute liver injury is unknown. We detected M1 muscarinic receptors (M1R) expression in human and murine hepatocytes, and investigated the consequences of M1R deficiency on acute liver injury in vivo and inhibiting M1R activation on hepatocyte in...

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Pubblicato in:Free Radic Biol Med
Autori principali: Urrunaga, Nathalie H., Jadeja, Ravirajsinh N., Rachakonda, Vikrant, Ahmad, Daniel, McLean, Leon P., Cheng, Kunrong, Shah, Vijay, Twaddell, William S., Raufman, Jean-Pierre, Khurana, Sandeep
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4392405/
https://ncbi.nlm.nih.gov/pubmed/25452146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2014.09.032
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