A Novel Phosphatidic Acid-Protein-tyrosine Phosphatase D2 Axis Is Essential for ERBB2 Signaling in Mammary Epithelial Cells

We used a loss-of-function screen to investigate the role of classical protein-tyrosine phosphatases (PTPs) in three-dimensional mammary epithelial cell morphogenesis and ERBB2 signaling. The study revealed a novel role for PTPD2 as a positive regulator of ERBB2 signaling. Suppression of PTPD2 atten...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Ramesh, Mathangi, Krishnan, Navasona, Muthuswamy, Senthil K., Tonks, Nicholas K.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2015
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4392266/
https://ncbi.nlm.nih.gov/pubmed/25681440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.627968
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