Receptor Protein-tyrosine Phosphatase α Regulates Focal Adhesion Kinase Phosphorylation and ErbB2 Oncoprotein-mediated Mammary Epithelial Cell Motility

We investigated the role of protein-tyrosine phosphatase α (PTPα) in regulating signaling by the ErbB2 oncoprotein in mammary epithelial cells. Using this model, we demonstrated that activation of ErbB2 led to the transient inactivation of PTPα, suggesting that attenuation of PTPα activity may contr...

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Bibliographische Detailangaben
Hauptverfasser: Boivin, Benoit, Chaudhary, Fauzia, Dickinson, Bryan C., Haque, Aftabul, Pero, Stephanie C., Chang, Christopher J., Tonks, Nicholas K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2013
Schlagworte:
Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3873551/
https://ncbi.nlm.nih.gov/pubmed/24217252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.527564
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