Receptor Protein-tyrosine Phosphatase α Regulates Focal Adhesion Kinase Phosphorylation and ErbB2 Oncoprotein-mediated Mammary Epithelial Cell Motility

We investigated the role of protein-tyrosine phosphatase α (PTPα) in regulating signaling by the ErbB2 oncoprotein in mammary epithelial cells. Using this model, we demonstrated that activation of ErbB2 led to the transient inactivation of PTPα, suggesting that attenuation of PTPα activity may contr...

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Detalhes bibliográficos
Main Authors: Boivin, Benoit, Chaudhary, Fauzia, Dickinson, Bryan C., Haque, Aftabul, Pero, Stephanie C., Chang, Christopher J., Tonks, Nicholas K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3873551/
https://ncbi.nlm.nih.gov/pubmed/24217252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.527564
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