Protein Kinase A (PknA) of Mycobacterium tuberculosis Is Independently Activated and Is Critical for Growth in Vitro and Survival of the Pathogen in the Host

The essential mycobacterial protein kinases PknA and PknB play crucial roles in modulating cell shape and division. However, the precise in vivo functional aspects of PknA have not been investigated. This study aims to dissect the role of PknA in mediating cell survival in vitro as well as in vivo....

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Foilsithe in:J Biol Chem
Main Authors: Nagarajan, Sathya Narayanan, Upadhyay, Sandeep, Chawla, Yogesh, Khan, Shazia, Naz, Saba, Subramanian, Jayashree, Gandotra, Sheetal, Nandicoori, Vinay Kumar
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2015
Ábhair:
Microbiology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4392265/
https://ncbi.nlm.nih.gov/pubmed/25713147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.611822
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