Protein kinases PknA and PknB independently and coordinately regulate essential Mycobacterium tuberculosis physiologies and antimicrobial susceptibility

The Mycobacterium tuberculosis Ser/Thr protein kinases PknA and PknB are essential for growth and have been proposed as possible drug targets. We used a titratable conditional depletion system to investigate the functions of these kinases. Depletion of PknA or PknB or both kinases resulted in growth...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS Pathog
Prif Awduron: Zeng, Jumei, Platig, John, Cheng, Tan-Yun, Ahmed, Saima, Skaf, Yara, Potluri, Lakshmi-Prasad, Schwartz, Daniel, Steen, Hanno, Moody, D. Branch, Husson, Robert N.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2020
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7164672/
https://ncbi.nlm.nih.gov/pubmed/32255801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008452
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