Increased IgG4 responses to multiple food and animal antigens indicate a polyclonal expansion and differentiation of pre-existing B cells in IgG4-related disease

BACKGROUND: IgG4-related disease (IgG4-RD) is a systemic fibroinflammatory condition, characterised by an elevated serum IgG4 concentration and abundant IgG4-positive plasma cells in the involved organs. An important question is whether the elevated IgG4 response is causal or a reflection of immune-...

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Detalles Bibliográficos
Publicado en:Ann Rheum Dis
Main Authors: Culver, Emma L, Vermeulen, Ellen, Makuch, Mateusz, van Leeuwen, Astrid, Sadler, Ross, Cargill, Tamsin, Klenerman, Paul, Aalberse, Rob C, van Ham, S Marieke, Barnes, Eleanor, Rispens, Theo
Formato: Artigo
Idioma:Inglês
Publicado: BMJ Publishing Group 2015
Assuntos:
Basic and Translational Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4392210/
https://ncbi.nlm.nih.gov/pubmed/25646372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2014-206405
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