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Psoriasis drug development and GWAS interpretation through in silico analysis of transcription factor binding sites

BACKGROUND: Psoriasis is a cytokine-mediated skin disease that can be treated effectively with immunosuppressive biologic agents. These medications, however, are not equally effective in all patients and are poorly suited for treating mild psoriasis. To develop more targeted therapies, interfering w...

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Detalhes bibliográficos
Publicado no:Clin Transl Med
Main Authors: Swindell, William R, Sarkar, Mrinal K, Stuart, Philip E, Voorhees, John J, Elder, James T, Johnston, Andrew, Gudjonsson, Johann E
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4392043/
https://ncbi.nlm.nih.gov/pubmed/25883770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40169-015-0054-5
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