Psoriasis drug development and GWAS interpretation through in silico analysis of transcription factor binding sites

BACKGROUND: Psoriasis is a cytokine-mediated skin disease that can be treated effectively with immunosuppressive biologic agents. These medications, however, are not equally effective in all patients and are poorly suited for treating mild psoriasis. To develop more targeted therapies, interfering w...

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Publicado en:Clin Transl Med
Autores principales: Swindell, William R, Sarkar, Mrinal K, Stuart, Philip E, Voorhees, John J, Elder, James T, Johnston, Andrew, Gudjonsson, Johann E
Formato: Artigo
Lenguaje:Inglês
Publicado: Springer Berlin Heidelberg 2015
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4392043/
https://ncbi.nlm.nih.gov/pubmed/25883770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40169-015-0054-5
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