Psoriasis drug development and GWAS interpretation through in silico analysis of transcription factor binding sites

BACKGROUND: Psoriasis is a cytokine-mediated skin disease that can be treated effectively with immunosuppressive biologic agents. These medications, however, are not equally effective in all patients and are poorly suited for treating mild psoriasis. To develop more targeted therapies, interfering w...

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Bibliografiske detaljer
Udgivet i:Clin Transl Med
Main Authors: Swindell, William R, Sarkar, Mrinal K, Stuart, Philip E, Voorhees, John J, Elder, James T, Johnston, Andrew, Gudjonsson, Johann E
Format: Artigo
Sprog:Inglês
Udgivet: Springer Berlin Heidelberg 2015
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4392043/
https://ncbi.nlm.nih.gov/pubmed/25883770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40169-015-0054-5
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