Psoriasis drug development and GWAS interpretation through in silico analysis of transcription factor binding sites

BACKGROUND: Psoriasis is a cytokine-mediated skin disease that can be treated effectively with immunosuppressive biologic agents. These medications, however, are not equally effective in all patients and are poorly suited for treating mild psoriasis. To develop more targeted therapies, interfering w...

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Vydáno v:Clin Transl Med
Hlavní autoři: Swindell, William R, Sarkar, Mrinal K, Stuart, Philip E, Voorhees, John J, Elder, James T, Johnston, Andrew, Gudjonsson, Johann E
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Berlin Heidelberg 2015
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Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4392043/
https://ncbi.nlm.nih.gov/pubmed/25883770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40169-015-0054-5
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