Psoriasis drug development and GWAS interpretation through in silico analysis of transcription factor binding sites

BACKGROUND: Psoriasis is a cytokine-mediated skin disease that can be treated effectively with immunosuppressive biologic agents. These medications, however, are not equally effective in all patients and are poorly suited for treating mild psoriasis. To develop more targeted therapies, interfering w...

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Bibliographic Details
Published in:Clin Transl Med
Main Authors: Swindell, William R, Sarkar, Mrinal K, Stuart, Philip E, Voorhees, John J, Elder, James T, Johnston, Andrew, Gudjonsson, Johann E
Format: Artigo
Language:Inglês
Published: Springer Berlin Heidelberg 2015
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4392043/
https://ncbi.nlm.nih.gov/pubmed/25883770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40169-015-0054-5
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