Development and analytical validation of a 25-gene next generation sequencing panel that includes the BRCA1 and BRCA2 genes to assess hereditary cancer risk

BACKGROUND: Germline DNA mutations that increase the susceptibility of a patient to certain cancers have been identified in various genes, and patients can be screened for mutations in these genes to assess their level of risk for developing cancer. Traditional methods using Sanger sequencing focus...

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: Judkins, Thaddeus, Leclair, Benoît, Bowles, Karla, Gutin, Natalia, Trost, Jeff, McCulloch, James, Bhatnagar, Satish, Murray, Adam, Craft, Jonathan, Wardell, Bryan, Bastian, Mark, Mitchell, Jeffrey, Chen, Jian, Tran, Thanh, Williams, Deborah, Potter, Jennifer, Jammulapati, Srikanth, Perry, Michael, Morris, Brian, Roa, Benjamin, Timms, Kirsten
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Technical Advance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4391687/
https://ncbi.nlm.nih.gov/pubmed/25886519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1224-y
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